Sergiusz Jozwiak Selected Research

Astrocytoma (Pilocytic Astrocytoma)

11/2022	Distinct DNA Methylation Patterns of Subependymal Giant Cell Astrocytomas in Tuberous Sclerosis Complex.
1/2021	Maintenance Therapy With Everolimus for Subependymal Giant Cell Astrocytoma in Patients With Tuberous Sclerosis - Final Results From the EMINENTS Study.
1/2021	Subependymal giant cell astrocytomas are characterized by mTORC1 hyperactivation, a very low somatic mutation rate, and a unique gene expression profile.
1/2020	The coding and non-coding transcriptional landscape of subependymal giant cell astrocytomas.
1/2020	Dysregulation of the MMP/TIMP Proteolytic System in Subependymal Giant Cell Astrocytomas in Patients With Tuberous Sclerosis Complex: Modulation of MMP by MicroRNA-320d In Vitro.
1/2019	Treatment Patterns and Use of Resources in Patients With Tuberous Sclerosis Complex: Insights From the TOSCA Registry.
1/2019	Clinical Characteristics of Subependymal Giant Cell Astrocytoma in Tuberous Sclerosis Complex.
1/2019	Newly Diagnosed and Growing Subependymal Giant Cell Astrocytoma in Adults With Tuberous Sclerosis Complex: Results From the International TOSCA Study.
6/2018	MicroRNA519d and microRNA4758 can identify gangliogliomas from dysembryoplastic neuroepithelial tumours and astrocytomas.
11/2017	Subependymal giant cell astrocytomas in Tuberous Sclerosis Complex have consistent TSC1/TSC2 biallelic inactivation, and no BRAF mutations.

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Sergiusz Jozwiak Research Topics

Disease

58	Tuberous Sclerosis (Bourneville's Disease) 11/2022 - 10/2002
24	Astrocytoma (Pilocytic Astrocytoma) 11/2022 - 12/2004
13	Epilepsy (Aura) 01/2022 - 03/2016
12	Neoplasms (Cancer) 01/2021 - 03/2006
10	Inborn Genetic Diseases (Disease, Hereditary) 01/2022 - 01/2013
10	Angiomyolipoma 01/2020 - 10/2002
9	Seizures (Absence Seizure) 01/2022 - 12/2008
5	Brain Neoplasms (Brain Tumor) 11/2022 - 04/2010
3	Autism Spectrum Disorder 01/2022 - 06/2019
3	Intellectual Disability (Idiocy) 01/2022 - 03/2016
3	Carcinogenesis 01/2020 - 04/2010
3	Neurocutaneous Syndromes (Phakomatoses) 01/2020 - 02/2009
3	Hamartoma 01/2020 - 10/2002
3	Autistic Disorder (Autism) 01/2020 - 01/2017
2	Glioblastoma (Glioblastoma Multiforme) 01/2021 - 06/2018
2	Rare Diseases (Rare Disease) 01/2021 - 11/2014
2	Infections 01/2021 - 04/2015
2	Infantile Spasms (West Syndrome) 01/2021 - 03/2019
2	Ganglioglioma 01/2021 - 06/2018
2	Stomatitis 01/2021 - 01/2013
2	Glioma (Gliomas) 01/2021 - 06/2018
2	Cognitive Dysfunction 10/2020 - 10/2010
2	Lymphangioleiomyomatosis (Lymphangiomyomatosis) 01/2019 - 01/2017
2	Brain Diseases (Brain Disorder) 01/2017 - 03/2016
2	Angiofibroma 01/2017 - 07/2013
2	Rhabdomyoma 01/2017 - 07/2013
2	Renal Cell Carcinoma (Grawitz Tumor) 04/2015 - 07/2014
1	Drug Resistant Epilepsy 01/2022
1	Neurodevelopmental Disorders 10/2021
1	Anemia 01/2021
1	Bronchitis 01/2021
1	Diarrhea 01/2021
1	Hyperglycemia 01/2021
1	Neurologic Manifestations (Neurological Manifestations) 01/2021
1	Neutropenia 01/2021
1	Hypertension (High Blood Pressure) 01/2020
1	Hydrocephalus (Hydrocephaly) 01/2020
1	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder) 01/2020
1	Focal Cortical Dysplasia 01/2019
1	Temporal Lobe Epilepsy 01/2019
1	Inflammation (Inflammations) 01/2017
1	Febrile Seizures (Febrile Seizure) 01/2017
1	Sepsis (Septicemia) 04/2015
1	Glandular and Epithelial Neoplasms (Neoplasms, Glandular) 07/2014
1	Fever (Fevers) 01/2013
1	Neurodegeneration with brain iron accumulation (NBIA) 10/2011
1	Neurodegenerative Diseases (Neurodegenerative Disease) 10/2011
1	Disease Progression 10/2010
1	Multiple Sclerosis 10/2010
1	Brain Injuries (Brain Injury) 01/2010
1	Persistent Vegetative State (Vegetative State) 01/2010
1	Pyridoxine-dependent epilepsy 12/2008
1	Status Epilepticus (Complex Partial Status Epilepticus) 12/2008
1	Nervous System Diseases (Neurological Disorders) 02/2008
1	Hypoxia (Hypoxemia) 01/2005

Drug/Important Bio-Agent (IBA)

52	trans-sodium crocetinate (crocetin)IBA 11/2022 - 10/2002
15	TOR Serine-Threonine KinasesIBA 01/2020 - 01/2007
13	Everolimus FDA Link 01/2021 - 01/2013
5	Proteins (Proteins, Gene)FDA Link 10/2020 - 01/2005
4	Sirolimus (Rapamycin)FDA Link 11/2022 - 03/2006
4	Biomarkers (Surrogate Marker)IBA 01/2022 - 01/2017
4	Mechanistic Target of Rapamycin Complex 1IBA 10/2021 - 01/2017
4	Vigabatrin FDA Link 01/2021 - 12/2019
4	Tuberous Sclerosis Complex 2 ProteinIBA 09/2016 - 01/2005
3	Anticonvulsants (Antiepileptic Drugs)IBA 12/2019 - 04/2015
3	Tuberous Sclerosis Complex 1 ProteinIBA 09/2016 - 01/2005
2	MTOR InhibitorsIBA 01/2019 - 11/2018
2	MicroRNAs (MicroRNA)IBA 06/2018 - 09/2016
2	IronIBA 01/2017 - 10/2011
1	Cell Adhesion MoleculesIBA 01/2022
1	RNA (Ribonucleic Acid)IBA 01/2021
1	SteroidsIBA 01/2021
1	Matrix Metalloproteinases (MMPs)IBA 01/2020
1	gamma-Aminobutyric Acid (GABA)IBA 03/2019
1	Aminobutyrates (Aminobutyric Acid)IBA 03/2019
1	Ion Channels (Ion Channel)IBA 01/2019
1	lipoarabinomannan (LAM)IBA 01/2019
1	HMGB1 Protein (HMG1)IBA 01/2017
1	CytokinesIBA 01/2017
1	Biological ProductsIBA 01/2017
1	Pharmaceutical PreparationsIBA 12/2015
1	Glutamate-Cysteine LigaseIBA 07/2015
1	Carbonic Anhydrase IXIBA 07/2014
1	Succinate Dehydrogenase (Fumarate Reductase)IBA 07/2014
1	VimentinIBA 07/2014
1	Phenytoin (Dilantin)FDA LinkGeneric 12/2008
1	Oxidoreductases (Dehydrogenase)IBA 12/2008
1	Phenobarbital (Luminal)FDA Link 12/2008
1	Pyridoxine (Pyridoxin)FDA LinkGeneric 12/2008
1	allysineIBA 12/2008
1	Midazolam (Versed)FDA LinkGeneric 12/2008
1	90-kDa Ribosomal Protein S6 Kinases (Ribosomal Protein S6 Kinases, 90 kDa)IBA 01/2007
1	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 01/2007
1	Ribosomal Protein S6 Kinases (S6 Kinase)IBA 01/2007
1	GTPase-Activating Proteins (GTPase-Activating Protein)IBA 01/2005
1	Interferon-gamma (Interferon, gamma)IBA 10/2002

Therapy/Procedure

10	Therapeutics 01/2021 - 03/2006
1	Duration of Therapy 01/2020
1	Transplantation 01/2010
1	Induced Heart Arrest (Cardioplegia) 01/2010